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The “MASTER HORMONE” that Regulates the body weight: LEPTIN

Why you always feel hungry??

According to the belief in society weight gain (and loss) is about calories and will power of an individual. However, according to the modern obesity research and scientist a hormone called” Leptin”, a protein made by fat cells in the body. Leptin was just discovered in 1994, and doctors believe it could hold the key to unlocking the physiology of obesity and weight gain. Being resistant to this hormone’s effects (called Leptin Resistance) is now believed to be the leading driver of fat gain in humans. Video link shows the full description how meal works in body fat.

What is Leptin??

It’s been called the “obesity hormone” or “fat hormone” — but also the “starvation hormone.” When scientists discovered Leptin in 1994, excitement arose about its potential as a blockbuster weight loss treatment. Leptin is known as the appetite or hunger control hormone. After you eat, your fat cells secrete leptin into the bloodstream, where it travels to the brain, signaling that you’re full. Someone whose leptin is functioning properly can eat to the point of satisfaction and not crave any more food. But when the brain struggles to detect the hormone, it doesn’t trigger that necessary response. This is called leptin resistance.

How Leptin affects in weight??

The problem is that overweight people have large amounts of leptin, but their brains aren’t getting the important signal to stop eating. “How come the brain doesn’t get it? That phenomenon is called ‘leptin resistance’. Leptin resistance is similar to insulin resistance in type 2 diabetes, in which the pancreas produces large amounts of insulin, but the body doesn’t respond to it properly. Leptin levels can keep going higher as people get fatter. “We all have a leptin floor; the problem is, we don’t have a leptin ceiling”.

Diagram showing working of Leptin :

What causes Leptin resistance??

Leptin resistance is still being researched, scientist don’t know the cause behind this. However, there’s evidence to suggest it’s related to being overweight. “We only know that leptin resistance is associated with certain other medical conditions, such as obesity, [and its related diseases] type 2 diabetes, thyroid issues, and elevated triglycerides in the bloodstream. A sedentary lifestyle and a diet rich in processed foods and simple carbohydrates could also lead to leptin resistance.

Does Leptin affects other body parts??

Leptin appears to have many functions that scientists are still exploring. “It didn’t work as a weight loss agent, but there’s now starting to be some other things that are really interesting about it:
1. The hormone plays a role in heart and bone health.
2. Leptin is very important in keeping the immune system happy
3. Some recent research suggests that leptin can promote the growth of melanoma, a type of skin cancer.
4. Leptin may even affect women’s fertility.